Uzbekistan coordinates its space activities through the Space Research and Technology Agency (Uzcosmos) under the Ministry of Digital Technologies of Uzbekistan. It was established by the Law of the Republic of Uzbekistan on Space Activities. The Ministry of Defense of the Republic of Uzbekistan is responsible for coordinating national security in the State.

The State participates in international space governance frameworks and is party to the Outer Space Treaty, Comprehensive Nuclear Test Ban Treaty, and the International Telecommunication Union Constitution and Convention.

Uzbekistan has been a member State to the Committee on the Peaceful Uses of Outer Space since 2022, is subscribing State to the Hague Code of Conduct Against Ballistic Missile Proliferation, and a Member State to the International Telecommunication Union.